Studies

Recent Completed Studies

Hydroxychloroquine Is Effective and Safe for the Treatment of COVID-19, and May be Universally Effective When Used Early Before Hospitalization: A Systematic Review

Introduction: Hydroxychloroquine (HCQ) has shown efficacy against COVID-19 in some but not all studies. We hypothesized that systematic review would show HCQ to be: effective against COVID-19, more effective when used earlier, not associated with worsening, and safe.

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Hydroxychloroquine Is Protective To The Heart, Not Harmful: A Systematic Review

Background: Hydroxychloroquine (HCQ) has been shown to be at least somewhat effective in treating COVID 19 patients. Recently FDA and CDC warnings of fatal cardiac toxicity from Torsade de Pointes (TDP) arrhythmia from HCQ use have been made, notwithstanding the long safe HCQ use for lupus and rheumatoid arthritis. This has resulted in restricted access of HCQ for COVID 19 treatment. We hypothesized that HCQ and azithromycin do not cause acute cardiac arrhythmic mortality.

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Injection of Autologous Mesenchymal Cells for the Treatment of Arthritis has so far been Found to be Completely Safe

Background: Injection of autologous mesenchymal stem cells (AMSCs) as stromal vascular fraction, culture expanded adipose derived stem cells, minimally manipulated fat graft, bone marrow aspirate or cultured bone marrow MSCs, for osteo- and inflammatory arthritis have shown good clinical efficacy in many studies. Questions have been raised as to their safety despite no evidence known to us that they are unsafe when used this way. We hypothesized that AMSC injections are completely safe for the treatment of arthritis.

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Autologous Biologic Treatment with Fat, Bone Marrow Aspirate and Platelet Rich Plasma Is an Effective Alternative to Total Knee Arthroplasty for Patients with Moderate Knee Arthrosis

Background: Osteoarthrosis (OA) of the knee afflicts millions worldwide. Total Knee Arthroplasty (TKA) is common, but associated with substantial cost and morbidity. Prior studies of intra-articular injection of fat, bone marrow aspirate (BMA), and platelet rich plasma (PRP) have shown clinical benefit. We hypothesized that injection of autologous adipose tissue, BMA, and PRP would provide significant benefit for patients with moderate knee OA resulting in avoidance of total knee arthroplasty (TKA) in most, with discontinuance of NSAIDs and other drugs.

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Autologous Mesenchymal Stem Cell Treatment is Consistently Effective for the Treatment of Knee Osteoarthritis: The Results of a Systematic Review of Treatment and Comparison to a Placebo Group

Background: Numerous studies have used autologous mesenchymal stem cell injections (AMSCI) to treat osteoarthritis. We hypothesized that AMSCI is an effective osteoarthritis treatment with increasing efficacy at higher doses.

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Low Level Laser – Combined Intra-articular Laser and Platelet Rich Plasma (PRP) Injection Reduces Pain in Patients Who Had Failed Prior PRP Treatment Presented at the World Association for Laser Therapy Biennial Meeting in Nice France October 3-5 2018

Stem Cell - Autologous Biologic Treatment with Fat, Bone Marrow Aspirate and Platelet Rich Plasma Is an Effective Alternative to Total Knee Arthroplasty for Patients with Moderate Knee Arthrosis. Accepted for publication in Medicines

Platelet Rich Plasma - Successful, Non Surgical Treatment of Rotator Cuff Tears with PRP (Platelet-Rich Plasma) Injections (in preparation for submission for publication)

Orthopaedic Surgery – Treatment of Type Two Slap Lesion With Anatomic Suture Anchor Repair Without Biceps Tenotomy Or Tenodesis (Published in the Open Orthopaedics Journal October 2018)

Stem Cell – Injection of Autologous Mesenchymal Cells for the Treatment of Arthritis has so far been Found to be Completely Safe. Submitted for publication

Stem Cell – Autologous Mesenchymal Stem Cell Treatment is Consistently Effective for the Treatment of Knee Osteoarthritis: The Results of a Systematic Review of Treatment and Comparison to a Placebo Group. Submitted for publication

Research Studies in Progress

PRP Stem Cell

Shoulder
  1. A new classification system for Shoulder Arthrosis Using the True AP or Grashey Radiographic View and comparison to traditional shoulder radiographs
  2. Efficacy of PRP injection for Arthrosis of the Glenohumeral Joint
  3. The efficacy of combined intra-tendinous and intra-articular PRP Injection for rotator cuff injury
Knee
  1. The effects of Varus and Valgus Angulation on the Results of Stem Cell and PRP Injection in the Arthritic Knee
  2. The Efficacy of Stem Cell and PRP Treatment for Knee Arthrosis as a function of joint space preservation
  3. Efficacy of PRP injection for the Treatment of Patellofemoral Arthrosis
  4. Efficacy of PRP injection for the Treatment of Patellofemoral Chondromalacia
TMJ

The efficacy and safety of PRP injection for TMJ degeneration

Hand/Wrist

The Benefit of PRP plus intra-articular laser compared to PRP alone for the treatment of first carpometacarpal arthrosis

Laser

Low Back Pain

The Efficacy of Low Level Laser Therapy for the treatment of Low Back Pain

Neck Pain

The efficacy of PBM/LLLT for the treatment of neck pain

TMJ

The Efficacy of Low Level Laser Therapy for Treatment of Disorders of theTemporomandibular Joint


Research Studies in Preparation

PRP – Stem Cell

  1. The effect of intra-articular effusion on the results of treatment of arthrosis of the knee with PRP or stem cell injection
  2. The efficacy of intra-articular and intravenous stromal vascular fraction injection on osteoarthrosis
  3. The efficacy of intravenous stromal vascular fraction in lowering blood glucose levels in type 1 and type 2 diabetes
  4. The efficacy of intravenous stromal vascular fraction injection in the treatment of rheumatoid arthritis
  5. The efficacy of intravenous stromal vascular fraction injection in the treatment of sero-positive autoimmune diseases

 

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